Cardiovascular manifestations in men and women carrying a FBN1 mutation
Identifieur interne : 007115 ( Main/Exploration ); précédent : 007114; suivant : 007116Cardiovascular manifestations in men and women carrying a FBN1 mutation
Auteurs : Delphine Détaint [France] ; Laurence Faivre [France] ; Gwenaelle Collod-Beroud [France] ; Anne H. Child [Royaume-Uni] ; Bart L. Loeys [Belgique] ; Christine Binquet [France] ; Elodie Gautier [France] ; Eloisa Arbustini [Italie] ; Karin Mayer [Allemagne] ; Mine Arslan-Kirchner [Allemagne] ; Chantal Stheneur [France] ; Dorothy Halliday [Royaume-Uni] ; Christophe Beroud [France] ; Claire Bonithon-Kopp [France] ; Mireille Claustres [France] ; Henri Plauchu [France] ; Peter N. Robinson [Allemagne] ; Anatoli Kiotsekoglou [Royaume-Uni] ; Julie De Backer [Belgique] ; Lesley Adès [Australie] ; Uta Francke [États-Unis] ; Anne De Paepe [Belgique] ; Catherine Boileau [France] ; Guillaume Jondeau [France]Source :
- European Heart Journal [ 0195-668X ] ; 2010-09.
Abstract
Aims In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery of a fibrillin-1 (FBN1) mutation. Methods and results A total of 1013 probands with pathogenic FBN1 mutations were included, among whom 965 patients [median age: 22 years (11–34), male gender 53%] had data suitable for analysis. The percentage of patients with an ascending aortic (AA) dilatation increased steadily with increasing age and reached 96% (95% CI: 94–97%) by 60 years. The presence of aortic events (dissection or prophylactic surgery) was rare before 20 years and then increased progressively, reaching 74% (95% CI: 67–81%) by 60 years. Compared with women, men were at higher risk for AA dilatation [≤30 years: 57% (95% CI: 52–63) vs. 50% (95% CI: 45–55), P = 0.0076] and aortic events [≤30 years: 21% (95% CI: 17–26) vs. 11% (95% CI: 8–16), P < 0.0001; adjusted HR: 1.4 (1.1–1.8), P = 0.005]. The prevalence of mitral valve (MV) prolapse [≤60 years: 77% (95% CI: 72–82)] and MV regurgitation [≤60 years: 61% (95% CI: 53–69)] also increased steadily with age, but surgery limited to the MV remained rare [≤60 years: 13% (95% CI: 8–21)]. No difference between genders was observed (for all P> 0.20). From 1985 to 2005 the prevalence of AA dilatation remained stable (P for trend = 0.88), whereas the percentage of patients with AA dissection significantly decreased (P for trend = 0.01). Conclusion The CV risk remains important in patients with an FBN1 gene mutation and is present throughout life, justifying regular aortic monitoring. Aortic dilatation or dissection should always trigger suspicion of a genetic background leading to thorough examination for extra-aortic features and comprehensive pedigree investigation.
Url:
DOI: 10.1093/eurheartj/ehq258
Affiliations:
- Allemagne, Australie, Belgique, France, Italie, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Basse-Saxe, Berlin, Bourgogne, Bourgogne-Franche-Comté, Californie, Grand Londres, Languedoc-Roussillon, Nouvelle-Galles du Sud, Occitanie (région administrative), Oxfordshire, Rhône-Alpes, Île-de-France
- Berlin, Hanovre, Londres, Lyon, Montpellier, Oxford, Paris, Sydney
- Université Montpellier 1, Université d'Oxford, Université de Sydney
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Loeys</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Binquet, Christine" sort="Binquet, Christine" uniqKey="Binquet C" first="Christine" last="Binquet">Christine Binquet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Dijon, Centre d'investigation clinique – épidémiologie clinique/essais cliniques, Dijon F-21000</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, CIE1, Dijon F-21000</wicri:regionArea><wicri:noRegion>21000</wicri:noRegion><wicri:noRegion>Dijon F-21000</wicri:noRegion></affiliation></author><author><name sortKey="Gautier, Elodie" sort="Gautier, Elodie" uniqKey="Gautier E" first="Elodie" last="Gautier">Elodie Gautier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Dijon, Centre d'investigation clinique – épidémiologie clinique/essais cliniques, Dijon F-21000</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, CIE1, Dijon F-21000</wicri:regionArea><wicri:noRegion>21000</wicri:noRegion><wicri:noRegion>Dijon F-21000</wicri:noRegion></affiliation></author><author><name sortKey="Arbustini, Eloisa" sort="Arbustini, Eloisa" uniqKey="Arbustini E" first="Eloisa" last="Arbustini">Eloisa Arbustini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Centre for Inherited Cardiovascular Diseases, Foundation IRCCS Policlinico San Matteo, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Human Genetics and Laboratory Medicine, Martinsried</wicri:regionArea><wicri:noRegion>Martinsried</wicri:noRegion><wicri:noRegion>Martinsried</wicri:noRegion></affiliation></author><author><name sortKey="Arslan Kirchner, Mine" sort="Arslan Kirchner, Mine" uniqKey="Arslan Kirchner M" first="Mine" last="Arslan-Kirchner">Mine Arslan-Kirchner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Stheneur, Chantal" sort="Stheneur, Chantal" uniqKey="Stheneur C" first="Chantal" last="Stheneur">Chantal Stheneur</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Ambroise Paré, Service de Pédiatrie, Boulogne F-92000</wicri:regionArea><wicri:noRegion>92000</wicri:noRegion><wicri:noRegion>Boulogne F-92000</wicri:noRegion></affiliation></author><author><name sortKey="Halliday, Dorothy" sort="Halliday, Dorothy" uniqKey="Halliday D" first="Dorothy" last="Halliday">Dorothy Halliday</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Biochemistry, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Beroud, Christophe" sort="Beroud, Christophe" uniqKey="Beroud C" first="Christophe" last="Beroud">Christophe Beroud</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U827, Montpellier F-34000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Montpellier I, Montpellier F-34000</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier F-34000</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Bonithon Kopp, Claire" sort="Bonithon Kopp, Claire" uniqKey="Bonithon Kopp C" first="Claire" last="Bonithon-Kopp">Claire Bonithon-Kopp</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CHU Dijon, Centre d'investigation clinique – épidémiologie clinique/essais cliniques, Dijon F-21000</wicri:regionArea><wicri:noRegion>21000</wicri:noRegion><wicri:noRegion>Dijon F-21000</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, CIE1, Dijon F-21000</wicri:regionArea><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Bourgogne</region></placeName></affiliation></author><author><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U827, Montpellier F-34000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Montpellier I, Montpellier F-34000</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>CHU Montpellier, Hôpital Arnaud de Villeneuve, Laboratoire de Génétique Moléculaire, Montpellier F-34000</wicri:regionArea><placeName><settlement type="city">Montpellier</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region></placeName></affiliation></author><author><name sortKey="Plauchu, Henri" sort="Plauchu, Henri" uniqKey="Plauchu H" first="Henri" last="Plauchu">Henri Plauchu</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Hôtel Dieu, Service de Génétique, Lyon F-69</wicri:regionArea><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Robinson, Peter N" sort="Robinson, Peter N" uniqKey="Robinson P" first="Peter N." last="Robinson">Peter N. Robinson</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Medizinische Genetik, Universitätsmedizin Charité, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kiotsekoglou, Anatoli" sort="Kiotsekoglou, Anatoli" uniqKey="Kiotsekoglou A" first="Anatoli" last="Kiotsekoglou">Anatoli Kiotsekoglou</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardic and vascular Sciences, St. George's Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="De Backer, Julie" sort="De Backer, Julie" uniqKey="De Backer J" first="Julie" last="De Backer">Julie De Backer</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Ades, Lesley" sort="Ades, Lesley" uniqKey="Ades L" first="Lesley" last="Adès">Lesley Adès</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Marfan Research Group, The Children's Hospital at Westmead, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics and Child Health, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Clinical Genetics, The Children's Hospital at Westmead, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Francke, Uta" sort="Francke, Uta" uniqKey="Francke U" first="Uta" last="Francke">Uta Francke</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Stanford University Medical Center, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Stanford University Medical Center, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="De Paepe, Anne" sort="De Paepe, Anne" uniqKey="De Paepe A" first="Anne" last="De Paepe">Anne De Paepe</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Center for Medical Genetics, Ghent University Hospital, Ghent</wicri:regionArea><wicri:noRegion>Ghent</wicri:noRegion></affiliation></author><author><name sortKey="Boileau, Catherine" sort="Boileau, Catherine" uniqKey="Boileau C" first="Catherine" last="Boileau">Catherine Boileau</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Ambroise Paré, Laboratoire de Génétique Moléculaire, Boulogne F-92000</wicri:regionArea><wicri:noRegion>92000</wicri:noRegion><wicri:noRegion>Boulogne F-92000</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Université Versailles-Saint Quentin en Yvelines, UFR P.I.F.O, Garches F-92380</wicri:regionArea><wicri:noRegion>92380</wicri:noRegion><wicri:noRegion>Garches F-92380</wicri:noRegion></affiliation></author><author><name sortKey="Jondeau, Guillaume" sort="Jondeau, Guillaume" uniqKey="Jondeau G" first="Guillaume" last="Jondeau">Guillaume Jondeau</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital Bichat, Consultation pluridisciplinaire Syndrome de Marfan et apparentés, Paris F-75018</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U698, Faculté Bichat, Paris VII, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-09">2010-09</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">18</biblScope><biblScope unit="page" from="2223">2223</biblScope><biblScope unit="page" to="2229">2229</biblScope></imprint><idno type="ISSN">0195-668X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Aims In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery of a fibrillin-1 (FBN1) mutation. Methods and results A total of 1013 probands with pathogenic FBN1 mutations were included, among whom 965 patients [median age: 22 years (11–34), male gender 53%] had data suitable for analysis. The percentage of patients with an ascending aortic (AA) dilatation increased steadily with increasing age and reached 96% (95% CI: 94–97%) by 60 years. The presence of aortic events (dissection or prophylactic surgery) was rare before 20 years and then increased progressively, reaching 74% (95% CI: 67–81%) by 60 years. Compared with women, men were at higher risk for AA dilatation [≤30 years: 57% (95% CI: 52–63) vs. 50% (95% CI: 45–55), P = 0.0076] and aortic events [≤30 years: 21% (95% CI: 17–26) vs. 11% (95% CI: 8–16), P < 0.0001; adjusted HR: 1.4 (1.1–1.8), P = 0.005]. The prevalence of mitral valve (MV) prolapse [≤60 years: 77% (95% CI: 72–82)] and MV regurgitation [≤60 years: 61% (95% CI: 53–69)] also increased steadily with age, but surgery limited to the MV remained rare [≤60 years: 13% (95% CI: 8–21)]. No difference between genders was observed (for all P> 0.20). From 1985 to 2005 the prevalence of AA dilatation remained stable (P for trend = 0.88), whereas the percentage of patients with AA dissection significantly decreased (P for trend = 0.01). Conclusion The CV risk remains important in patients with an FBN1 gene mutation and is present throughout life, justifying regular aortic monitoring. Aortic dilatation or dissection should always trigger suspicion of a genetic background leading to thorough examination for extra-aortic features and comprehensive pedigree investigation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Basse-Saxe</li><li>Berlin</li><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Californie</li><li>Grand Londres</li><li>Languedoc-Roussillon</li><li>Nouvelle-Galles du Sud</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Hanovre</li><li>Londres</li><li>Lyon</li><li>Montpellier</li><li>Oxford</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université Montpellier 1</li><li>Université d'Oxford</li><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Detaint, Delphine" sort="Detaint, Delphine" uniqKey="Detaint D" first="Delphine" last="Détaint">Delphine Détaint</name></region><name sortKey="Beroud, Christophe" sort="Beroud, Christophe" uniqKey="Beroud C" first="Christophe" last="Beroud">Christophe Beroud</name><name sortKey="Beroud, Christophe" sort="Beroud, Christophe" uniqKey="Beroud C" first="Christophe" last="Beroud">Christophe Beroud</name><name sortKey="Beroud, Christophe" sort="Beroud, Christophe" uniqKey="Beroud C" first="Christophe" last="Beroud">Christophe Beroud</name><name sortKey="Binquet, Christine" sort="Binquet, Christine" uniqKey="Binquet C" first="Christine" last="Binquet">Christine Binquet</name><name sortKey="Binquet, Christine" sort="Binquet, Christine" uniqKey="Binquet C" first="Christine" last="Binquet">Christine Binquet</name><name sortKey="Boileau, Catherine" sort="Boileau, Catherine" uniqKey="Boileau C" first="Catherine" last="Boileau">Catherine Boileau</name><name sortKey="Boileau, Catherine" sort="Boileau, Catherine" uniqKey="Boileau C" first="Catherine" last="Boileau">Catherine Boileau</name><name sortKey="Bonithon Kopp, Claire" sort="Bonithon Kopp, Claire" uniqKey="Bonithon Kopp C" first="Claire" last="Bonithon-Kopp">Claire Bonithon-Kopp</name><name sortKey="Bonithon Kopp, Claire" sort="Bonithon Kopp, Claire" uniqKey="Bonithon Kopp C" first="Claire" last="Bonithon-Kopp">Claire Bonithon-Kopp</name><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><name sortKey="Claustres, Mireille" sort="Claustres, Mireille" uniqKey="Claustres M" first="Mireille" last="Claustres">Mireille Claustres</name><name sortKey="Collod Beroud, Gwenaelle" sort="Collod Beroud, Gwenaelle" uniqKey="Collod Beroud G" first="Gwenaelle" last="Collod-Beroud">Gwenaelle Collod-Beroud</name><name sortKey="Collod Beroud, Gwenaelle" sort="Collod Beroud, Gwenaelle" uniqKey="Collod Beroud G" first="Gwenaelle" last="Collod-Beroud">Gwenaelle Collod-Beroud</name><name sortKey="Detaint, Delphine" sort="Detaint, Delphine" uniqKey="Detaint D" first="Delphine" last="Détaint">Delphine Détaint</name><name sortKey="Detaint, Delphine" sort="Detaint, Delphine" uniqKey="Detaint D" first="Delphine" last="Détaint">Delphine Détaint</name><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><name sortKey="Gautier, Elodie" sort="Gautier, Elodie" uniqKey="Gautier E" first="Elodie" last="Gautier">Elodie Gautier</name><name sortKey="Gautier, Elodie" sort="Gautier, Elodie" uniqKey="Gautier E" first="Elodie" last="Gautier">Elodie Gautier</name><name sortKey="Jondeau, Guillaume" sort="Jondeau, Guillaume" uniqKey="Jondeau G" first="Guillaume" last="Jondeau">Guillaume Jondeau</name><name sortKey="Jondeau, Guillaume" sort="Jondeau, Guillaume" uniqKey="Jondeau G" first="Guillaume" last="Jondeau">Guillaume Jondeau</name><name sortKey="Plauchu, Henri" sort="Plauchu, Henri" uniqKey="Plauchu H" first="Henri" last="Plauchu">Henri Plauchu</name><name sortKey="Stheneur, Chantal" sort="Stheneur, Chantal" uniqKey="Stheneur C" first="Chantal" last="Stheneur">Chantal Stheneur</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Child, Anne H" sort="Child, Anne H" uniqKey="Child A" first="Anne H." last="Child">Anne H. Child</name></region><name sortKey="Halliday, Dorothy" sort="Halliday, Dorothy" uniqKey="Halliday D" first="Dorothy" last="Halliday">Dorothy Halliday</name><name sortKey="Kiotsekoglou, Anatoli" sort="Kiotsekoglou, Anatoli" uniqKey="Kiotsekoglou A" first="Anatoli" last="Kiotsekoglou">Anatoli Kiotsekoglou</name></country><country name="Belgique"><noRegion><name sortKey="Loeys, Bart L" sort="Loeys, Bart L" uniqKey="Loeys B" first="Bart L." last="Loeys">Bart L. Loeys</name></noRegion><name sortKey="De Backer, Julie" sort="De Backer, Julie" uniqKey="De Backer J" first="Julie" last="De Backer">Julie De Backer</name><name sortKey="De Paepe, Anne" sort="De Paepe, Anne" uniqKey="De Paepe A" first="Anne" last="De Paepe">Anne De Paepe</name></country><country name="Italie"><noRegion><name sortKey="Arbustini, Eloisa" sort="Arbustini, Eloisa" uniqKey="Arbustini E" first="Eloisa" last="Arbustini">Eloisa Arbustini</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name></noRegion><name sortKey="Arslan Kirchner, Mine" sort="Arslan Kirchner, Mine" uniqKey="Arslan Kirchner M" first="Mine" last="Arslan-Kirchner">Mine Arslan-Kirchner</name><name sortKey="Robinson, Peter N" sort="Robinson, Peter N" uniqKey="Robinson P" first="Peter N." last="Robinson">Peter N. Robinson</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Ades, Lesley" sort="Ades, Lesley" uniqKey="Ades L" first="Lesley" last="Adès">Lesley Adès</name></region><name sortKey="Ades, Lesley" sort="Ades, Lesley" uniqKey="Ades L" first="Lesley" last="Adès">Lesley Adès</name><name sortKey="Ades, Lesley" sort="Ades, Lesley" uniqKey="Ades L" first="Lesley" last="Adès">Lesley Adès</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Francke, Uta" sort="Francke, Uta" uniqKey="Francke U" first="Uta" last="Francke">Uta Francke</name></region><name sortKey="Francke, Uta" sort="Francke, Uta" uniqKey="Francke U" first="Uta" last="Francke">Uta Francke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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